Interaction of AI-Enabled Quantitative Coronary Plaque Volumes on Coronary CT Angiography, FFR CT , and Clinical Outcomes: A Retrospective Analysis of the ADVANCE Registry
Authors' conclusion
Analysis of the ADVANCE registry using artificial intelligence-enabled quantitative plaque analysis shows that total plaque volume is associated with one-year adverse clinical events, with incremental predictive value over luminal stenosis or abnormal physiology by FFRCT.
Study context
- Population
- Patients with coronary CT angiography and one-year outcome data, ADVANCE registry
- Participants
- 4,430 patients
- Exposure
- Plaque volume above vs below ROC-derived optimal cutoff
- Outcome
- MACE, late revascularization, their composite, and CV death/MI
- Follow-up
- One year
Methodological detailsinternational registry, AI-enabled quantitative plaque analysis, multivariable-adjusted
- International registry
- AI-enabled quantitative plaque analysis
- Multivariable-adjusted
Main finding
As reported in the abstract
MACE/late revascularization composite
Estimate (95% CI)P value
Total plaque volume >564 mm³also associated with both components
adjusted HR 1.515(1.093–2.099)
P = 0.0126Total percent atheroma volume >24.4%
HR 2.046(1.474–2.839)
P < 0.0001Observational data: associations, not effects.
Further findings
CV death/MI · one year
| HR (95% CI) | P value | ||
|---|---|---|---|
| Total percent atheroma volume >37.17% | 4.53 (1.943–10.576) | P = 0.0005 | |
| 0.050.21520Hazard ratio (log scale) |
Calcified, noncalcified and low-attenuation percentage atheroma volumes above optimal cutoff
- Associated with all adverse outcomes; not maintained for CV death/MI in analyses stratified by median plaque volumes
Original publication
Interaction of AI-Enabled Quantitative Coronary Plaque Volumes on Coronary CT Angiography, FFR CT , and Clinical Outcomes: A Retrospective Analysis of the ADVANCE Registry. Circ Cardiovasc Imaging. Published 12 March 2024. doi:10.
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