Heart failure & cardiomyopathiesSecondary analysis
Interleukin-6 in Patients With Heart Failure and Preserved Ejection Fraction
- Secondary analysis of 4 NHLBI-sponsored randomised trials
- pooled analysis
- analysis by IL-6 tertiles
Authors' conclusion
IL-6 levels are commonly elevated in HFpEF, and are associated with greater symptom severity, poorer exercise capacity, and more upper body fat accumulation.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF) enrolled in 4 NHLBI-sponsored trials
- Participants
- 374 patients
- Comparison
- Tertiles of IL-6 concentration
Primary result
As reported in the abstract
Exercise capacity by IL-6 tertile (highest to lowest IL-6, as printed)
Peak oxygen consumption (mean ± SD, mL/kg/min), across tertiles: 12.3 ± 3.3, 13.1 ± 3.1, 14.4 ± 3.9; more severely impaired with highest IL-6
P < 0.0001
6-minute walk distance (mean ± SD, m), across tertiles: 276 ± 107 vs 332 ± 106 vs 352 ± 116; more severely impaired with highest IL-6
P < 0.0001
Further findings
Baseline characteristics, highest IL-6 tertile
- Greater BMI; higher NT-proBNP, C-reactive protein and TNF-α; worse renal function; lower hemoglobin; more likely to have diabetes
Cardiac structure and function at rest
- Similar across IL-6 tertiles
Body composition, symptoms and health status
- IL-6 associated with increases in total body fat and trunk fat, more severe symptoms during submaximal exercise, and poorer patient-reported health status
Original publication
Interleukin-6 in Patients With Heart Failure and Preserved Ejection Fraction. JACC Heart Fail. Published 9 August 2023. doi:10.1016/j.jchf.2023.06.031
Summarised from the published abstract; every number is checked against it