Heart failure & cardiomyopathies
Interplay between acute heart failure and chronic obstructive pulmonary disease (COPD) in patients hospitalized for dysponea: prognostic insights from the PARADISE cohort
Authors' conclusion
HF and COPD frequently coexist and are both associated with an increased long-term mortality risk, with a greater prognostic impact of HF in patients with COPD. These findings highlight the importance of systematic identification and optimized management of both conditions in this high-risk population.
Study context
- Population
- Patients admitted to the emergency department (ED) for acute dyspnoea between 2010 and 2019 with a primary diagnosis of heart failure (HF) or COPD, stratified according to the presence of the alternate conditionprimary diagnosis of HF 3,543 · primary diagnosis of COPD 1,588
- Participants
- 5,131 patients
- Exposure
- Patients with a primary diagnosis of HF or COPD stratified according to the presence of the alternate condition
- Outcome
- In-hospital and post-discharge all-cause mortality
Main finding
As reported in the abstract
In-hospital and post-discharge all-cause mortality
Primary HF with COPD
- In-hospital mortality
- 8.5%
- Overall mortality
- 69.3%
Primary HF without COPD
- In-hospital mortality
- 11.7%
- Overall mortality
- 68.9%
Primary COPD with HF
- In-hospital mortality
- 7.4%
- Long-term mortality
- 68.7%
Primary COPD without HF
- In-hospital mortality
- 3.4%
- Long-term mortality
- 48.7%
In-hospital mortality
Primary HF with COPD8.5%
Primary HF without COPD11.7%
Primary COPD with HF7.4%
Primary COPD without HF3.4%
Overall mortality
Primary HF with COPD69.3%
Primary HF without COPD68.9%
Primary COPD with HFNot reported in the abstract
Primary COPD without HFNot reported in the abstract
Long-term mortality
Primary HF with COPDNot reported in the abstract
Primary HF without COPDNot reported in the abstract
Primary COPD with HF68.7%
Primary COPD without HF48.7%
Estimate (95% CI)P value
Primary HF with COPD vs Primary HF without COPDadjusted; in-hospital mortality
OR 0.74(0.55–0.99)
P = 0.050Primary HF with COPD vs Primary HF without COPDadjusted; long-term mortality
HR 1.22(1.09–1.36)
P < 0.001Primary COPD with HF vs Primary COPD without HFadjusted; in-hospital mortality
OR 1.54(0.87–2.65)
P = 0.13Primary COPD with HF vs Primary COPD without HFadjusted; long-term mortality
HR 1.48(1.25–1.76)
P < 0.001Observational data: associations, not effects.
Further findings
Concomitant disease
- Concomitant disease present in both groups
- ≈20%
Original publication
Interplay between acute heart failure and COPD in patients hospitalized for dysponea: prognostic insights from the PARADISE cohort. ESC Heart Fail. Published 23 May 2026. doi:10.
Summarised from the published abstract; every number is checked against it