Prevention & lipidsMeta-analysis
Interventions to improve adherence among patients prescribed statins for primary prevention of cardiovascular diseases: a systematic review and meta-analysis
- Systematic review and meta-analysis
Authors' conclusion
The study found heterogenous evidence with limited certainty suggesting a potential modest improvement in statin adherence with interventions, where the effect sizes were small.
Study context
- Population
- Patients receiving statins for primary prevention of CVD34 studies
- Comparison
- Adherence interventions vs control
- Outcome
- Statin adherence
Pooled result
As reported in the abstract
Intervention vs ControlRelative risk (95% CI)
ncRCTs (18)
1.12(1.00–1.25)
cRCTs (10)
1.50(0.97–2.31)
NRSI (6)
1.37(0.95–1.98)
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| Statin adherence, by intervention component (subgroup) — Intervention vs Control · digital components, ncRCTs | 1.08 (1.03–1.12) | |
| Statin adherence, by intervention component (subgroup) — Intervention vs Control · digital components, cRCTs | 1.30 (1.07–1.59) | |
| Statin adherence, by intervention component (subgroup) — Intervention vs Control · education-based, ncRCTs | 1.05 (1.02–1.09) | |
| Statin adherence, by intervention component (subgroup) — Intervention vs Control · multifaceted, ncRCTs | 1.11 (1.07–1.16) | |
| 0.512Relative risk (log scale) |
LDL-C and TC
- Interventions effective in lowering LDL-C but not as effective in lowering TC
Original publication
Interventions to improve adherence among patients prescribed statins for primary prevention of cardiovascular diseases: a systematic review and meta-analysis. Eur J Prev Cardiol. Published 27 March 2026. doi:10.1093/eurjpc/zwag175
Summarised from the published abstract; every number is checked against it