Arrhythmias & electrophysiology
Intrapericardial Corticosteroids and Colchicine Prevent Pericarditis and Atrial Fibrillation After Epicardial Ablation of Ventricular Arrhythmias
Authors' conclusion
The instillation of intrapericardial steroids along with periprocedural colchicine after epicardial VT ablation led to a decreased incidence of adverse effects associated with pericardial inflammation when compared with historical control groups. Further research with contemporary control groups is needed to confirm the suggested impact of the strategy described here.
Study context
- Population
- Patients undergoing epicardial ventricular tachycardia (VT) ablation between June 2021 and December 2023patients who underwent epicardial VT ablation with subsequent ISI and colchicine therapy
- Participants
- 129 patients
- Exposure
- ISI combined with periprocedural colchicine vs historical control groups
- ISI and colchicinen = 129
- Outcome
- Occurrence of pericarditis (pericarditic chest pain and pericarditic electrocardiographic (ECG) changes)
Methodological detailshistorical control groups identified by systematic literature search
- Historical control groups identified by systematic literature search
Main finding
As reported in the abstract
ISI and colchicine vs historical control groups: P = 0.109 · ISI and colchicine vs intrapericardial steroids: P = 0.030
Observational data: associations, not effects.
Secondary outcomes
| Outcome | ISI and colchicine | Historical control groups | P value |
|---|---|---|---|
| Pericarditic painISI and colchicine vs historical control groups · significantly lower in our study | 10.9% | 30.9% | P = 0.001 |
| Pericarditic ECG changesISI and colchicine vs historical control groups · significantly lower in our study | 5.4% | 33.8% | P < 0.001 |
| New-onset atrial fibrillationISI and colchicine vs historical control groups · significantly lower in our study | 0.8% | 19.5% | P = <0.001 |
Original publication
Intrapericardial Corticosteroids and Colchicine Prevent Pericarditis and Atrial Fibrillation After Epicardial Ablation of Ventricular Arrhythmias. JACC Clin Electrophysiol. Published 22 January 2025. doi:10.
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