Aortic & peripheral vascular disease
Intraplaque Myeloperoxidase Activity as Biomarker of Unstable Atheroma and Adverse Clinical Outcomes in Human Atherosclerosis
Authors' conclusion
MPO is active within unstable human plaques and correlates with symptomatic carotid disease and stroke, yet current imaging parameters do not identify plaques with active MPO.
Study context
- Population
- Human carotid endarterectomy specimens and coronary trees31 CEA specimens · 12 coronary trees
- Comparison
- Unstable vs stable atherosclerotic plaque
- Outcome
- Intraplaque MPO activity (hydroethidine conversion to 2-chloroethidium)
Main finding
As reported in the abstract
MPO activity, unstable vs stable plaque
- Unstable vs Stable: P < 0.0001
- Unstable vs Stable: P = 0.0006
- Mann-Whitney U and Kruskal-Wallis tests
Further findings
| Outcome | P value |
|---|---|
| MPO activity, asymptomatic stroke-free vs symptomatic or ipsilateral stroke | P = 0.002 |
| MPO activity by CT-determined plaque attenuationHigh attenuation vs Low attenuation · n = 30; 0.1 ± 0.1 vs 0.2 ± 0.3; did not differentiate | P = 0.23 |
- Myeloperoxidase (MPO) activity, asymptomatic stroke-free vs symptomatic or ipsilateral stroke: n = 12; 3.7 ± 2.1 vs 0.1 ± 0.2 (as printed); lower MPO activity in asymptomatic, stroke-free
MPO activity in perivascular adipose tissue
- MPO activity not found in perivascular adipose tissue
Original publication
Intraplaque Myeloperoxidase Activity as Biomarker of Unstable Atheroma and Adverse Clinical Outcomes in Human Atherosclerosis. JACC Adv. Published 26 April 2023. doi:10.
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