Acute cardiac care & resuscitation
Intravenous or intraosseous vascular access in cardiac arrest: an individual participant data meta-analysis
Pooled result · 30-day survivalResult — go to the resultOdds ratio 1.01 95% CI 0.81–1.25Authors' conclusion
In this individual participant data meta-analysis of two randomized trials, intraosseous-first compared with intravenous-first vascular access during out-of-hospital cardiac arrest did not result in a statistically significant difference in 30-day survival, sustained return of spontaneous circulation, and favorable neurological outcome.
Study context
- Population
- Patients with out-of-hospital cardiac arrest in randomized trials comparing intraosseous-first with intravenous-first vascular accessTwo randomized trials provided individual participant data
- Participants
- 7,561 patients
- Comparison
- Intraosseous-first compared with intravenous-first vascular access during cardiac arrest
- Outcome
- 30-day survival
- Follow-up
- 30 days
Methodological detailsPRISMA-IPD, logistic regression with adjustment for prognostic factors, Bayesian analyses using prespecified prior distributions, GRADE methodology
- PRISMA-IPD
- Logistic regression with adjustment for prognostic factors
- Bayesian analyses using prespecified prior distributions
- GRADE methodology
Pooled result
As reported in the abstract
Odds ratio
1.01
95% CI 0.81–1.25
Intraosseousvs intravenous
odds ratio 1.01 (95% CI 0.81–1.25)
Further pooled results
| Outcome | Odds ratio (95% CI) | |
|---|---|---|
| Favorable neurological outcome · 30 days or hospital dischargeLow certainty of evidence | 1.08 (0.83–1.41) | |
| Sustained return of spontaneous circulation | 0.90 (0.81–1.01) | |
| 0.512Odds ratio (log scale) |
- Sustained return of spontaneous circulation: point estimate favored intravenous access; not statistically significant; low certainty of evidence
Bayesian analyses
- High probability that any difference between the two strategies was small
Original publication
Intravenous or intraosseous vascular access in cardiac arrest: an individual participant data meta-analysis. Resuscitation. Published 11 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →