Invasive Coronary Function Testing in Patients With Prior PCI Who Have Persistent ANOCA
Authors' conclusion
Patients with post-PCI persistent angina have severe symptoms and poor quality of life, with the majority exhibiting endothelial dysfunction, epicardial spasm, coronary microvascular dysfunction, and myocardial bridging. Comprehensive CFT should be considered in these patients to help diagnose an underlying cause of their persistent angina and guide therapy for a better outcome.
Study context
- Population
- Patients with a prior PCI experiencing persistent angina with no obstructive coronary artery diseasepatients with a prior PCI experiencing persistent angina
- Participants
- 46 patients
- Outcome
- Baseline characteristics
Main finding
As reported in the abstract
- Median age
- 60 (53-69) years
- Women
- 63%
- Pre-PCI lesion stenosis
- 80 (70-90)%
- Pre-PCI fractional flow reserve (n=7)
- 0.72 (0.67-0.74)
- Left anterior descending artery PCI
- 47.8%
- Median duration between PCI and coronary function testing (CFT)
- 19.5 (11.2-57.2) months
Further findings
CFT findings
- Median fractional flow reserve
- 0.84 (0.82-0.87)
- Fractional flow reserve ≤0.8
- 19.6%
- Endothelial dysfunction
- 36.9%
- Moderate to severe endothelial dysfunction, of those with endothelial dysfunction
- 64.7%
- Epicardial spasm
- 56.5%
- Microvascular spasm
- 17.4%
- Coronary microvascular dysfunction
- 43.5%
- Myocardial bridging
- 63%
Seattle Angina Questionnaire scores · 1-year post-CFT
- Significant improvement
Original publication
Invasive Coronary Function Testing in Patients With Prior PCI Who Have Persistent ANOCA. Circ Cardiovasc Interv. Published 25 June 2025. doi:10.
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