Acute cardiac care & resuscitation
Investigating the Association Between Atrial Fibrillation and Out-of-Hospital Cardiac Arrest: A Danish Nationwide Matched Cohort Study
Main finding · OHCAResult — go to the resultAdjusted hazard ratio 1.66 95% CI 1.62–1.70Authors' conclusion
Findings suggest that AF remains a risk factor for OHCA, even after adjustments for ischemic heart disease and heart failure. Future studies should explore subsets of patients with AF at highest risk of OHCA to tailor preventive efforts toward this patient group.
Study context
- Population
- Individuals aged 18 to 85 years in the Danish Cardiac Arrest Registry (June 1, 2001, to December 31, 2022)individuals included, of whom 368,639 had atrial fibrillation (AF), 309,010 newly diagnosed AF patients matched to 1,236,040 non-AF patients
- Participants
- 6.47 million individuals
- Exposure
- AF patients vs non-AF patients
- AF patientsn = 309,010
- non-AF patientsn = 1,236,040reference
- Outcome
- Out-of-hospital cardiac arrest (OHCA)
Methodological details1:4 matching, multivariable Cox regression
- 1:4 matching
- Multivariable Cox regression
Main finding
As reported in the abstract
Adjusted hazard ratio
1.66
95% CI 1.62–1.70
AF patientsvs non-AF patients
Adjusted HR 1.66 (95% CI 1.62–1.70)
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | |
|---|---|---|
| All-cause mortalityMatched cohort | 1.79 (1.78–1.81) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Investigating the Association Between Atrial Fibrillation and Out-of-Hospital Cardiac Arrest: A Danish Nationwide Matched Cohort Study. JACC Clin Electrophysiol. Published 24 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →