Heart failure & cardiomyopathies
Investigation of Left Ventricular Ejection Fraction in a Swiss Heart Failure Population: Insights Into Mortality and Sex Differences
Authors' conclusion
The prognostic role of LVEF on all-cause mortality remains unclear, while differences in mortality rate distribution between women and men mirror established HF pathophysiological sex differences.
Study context
- Population
- Heart failure (HF) patients admitted to the University Hospital of Bern, January 2015 to December 20192,912 died
- Participants
- 5,824 patients
- Exposure
- HF with Preserved Ejection Fraction (HFpEF) vs HF with Mid-range Ejection Fraction (HFmrEF) vs HFrEF
- Outcome
- All-cause mortality by LVEF category
- Follow-up
- Median 3.39 years
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Mortality across LVEF categories
- No significant differences in mortality rates across left ventricular ejection fraction (LVEF) categories
- Women had significantly higher mortality overall
- Adjusted Cox proportional hazard models
Observational data: associations, not effects.
Further findings
30-day mortality, HFpEF
| HR (95% CI) | P value | ||
|---|---|---|---|
| HFpEFOverall | 0.67 (0.52–0.88) | P = 0.003 | |
| HFpEFMales | 0.59 (0.42–0.81) | P < 0.001 | |
| HFpEFNon-diabetics | 0.62 (0.44–0.87) | P = 0.005 | |
| 0.512Hazard ratio (log scale) |
Mortality after 1 year, HFpEF, females (subgroup)
| HR (95% CI) | P value | ||
|---|---|---|---|
| HFpEFFemales | 0.72 (0.53–0.98) | P = 0.035 | |
| 0.512Hazard ratio (log scale) |
Original publication
Investigation of Left Ventricular Ejection Fraction in a Swiss Heart Failure Population: Insights Into Mortality and Sex Differences. ESC Heart Fail. Published 10 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →