Heart failure & cardiomyopathies

Iron Deficiency, Anemia, and Iron Supplementation in Patients With Heart Failure: A Population-Level Study

Circ Heart FailPublished Population-based retrospective cohort study

Authors' conclusion

Current practices for investigating and treating ID in patients with HF do not align with existing guideline recommendations.

Study context

Population
Adults with Heart Failure (HF) in Alberta, Canada, 2012–2019
Participants
17,463 vs 11,320
Exposure
Acute HF vs chronic HF
  • Acute HFn = 17,463
  • Chronic HFn = 11,320
Outcome
Iron studies testing, prevalence of iron deficiency (ID) and ID anemia (IDA), and iron supplementation
Follow-up
Within 30 days post-index-HF episode
Methodological detailspopulation-level, single-payer health care system
  • Population-level
  • Single-payer health care system

Main finding

As reported in the abstract

Iron studies tested, ID, IDA and iron therapy

Iron studies tested

ID (among tested)

IDA (among tested)

Iron therapy in IDA

Iron therapy in ID without anemia

Observational data: associations, not effects.

Further findings

Type of iron therapy

Oral iron most common
28.1%

Eligibility for AFFIRM-AHF, IRONMAN and HEART-FID trials

Approximately half of the cohort eligible for each trial

Original publication

Iron Deficiency, Anemia, and Iron Supplementation in Patients With Heart Failure: A Population-Level Study. Circ Heart Fail. Published 4 April 2024. doi:10.1161/circheartfailure.123.011351

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