Heart failure & cardiomyopathies
Is Excessive Ventricular Irregularity Predictive of Rehospitalization in Patients with Permanent Atrial Fibrillation (AF) and Heart Failure with Preserved Ejection Fraction (HFpEF)?
Authors' conclusion
In this pilot study, we found some evidences for a deleterious impact of excessive ventricular irregularity on HFrH in AF patients with HFpEF.
Study context
- Population
- Patients with HFpEF and permanent AF with 24 h Holter within a month after a first HF hospitalization, 2010–2021216 screened
- Participants
- 51 patients
- Exposure
- HFrH vs No HFrH
- HFrHn = 29
- Outcome
- Rehospitalization for acute HF (HFrH)
- Follow-up
- Median 3.13 years
Methodological detailssingle-centre, pilot study
- Single-centre
- Pilot study
Main finding
As reported in the abstract
Ventricular irregularity parameters, HFrH vs no HFrH
| Group | Value | SDNN | CV-SDNN | RMSSD | pNN50 |
|---|---|---|---|---|---|
| HFrH | 29 events | 205 ± 65 ms | 26 ± 8% | 182 ± 47 ms | 76 ± 9 |
| No HFrH | 154 ± 46 ms | 19 ± 5% | 138 ± 65 ms | 58 ± 26 |
Value
HFrH29 events
No HFrHNot reported in the abstract
SDNN
HFrH205 ± 65 ms
No HFrH154 ± 46 ms
CV-SDNN
HFrH26 ± 8%
No HFrH19 ± 5%
RMSSD
HFrH182 ± 47 ms
No HFrH138 ± 65 ms
pNN50
HFrH76 ± 9
No HFrH58 ± 26
- HFrH vs No HFrH: P < 0.01 — SDNN
- HFrH vs No HFrH: P < 0.01 — CV-SDNN
- HFrH vs No HFrH: P = 0.013 — RMSSD
- HFrH vs No HFrH: P < 0.001 — pNN50
Observational data: associations, not effects.
Original publication
Is Excessive Ventricular Irregularity Predictive of Rehospitalization in Patients with Permanent AF and HFpEF? ESC Heart Fail. Published 20 March 2023. doi:10.
Summarised from the published abstract; every number is checked against it