Construct and Predictive Validity of the Kansas City Cardiomyopathy Questionnaire in Adult Congenital Heart Disease
Authors' conclusion
The KCCQ has construct and predictive utility in ACHD and provides an opportunity to assess health status in ACHD both clinically and in future ACHD research.
Study context
- Population
- Ambulatory adult congenital heart disease (ACHD) patients who completed the Kansas City Cardiomyopathy Questionnaire (KCCQ)patients completed 129 KCCQs, predictive validity analysis N = 92 · predictive validity analysis 92
- Participants
- 109 participants
- Exposure
- KCCQ scores compared across ACHD complexity categories, disease characteristics and physiologic failure, and within 2 primary composite outcomes
- Outcome
- Death or all-cause hospitalization (DH) and death or interventional cardiac procedures (DP)
- Follow-up
- Median 16.3 months
Main finding
As reported in the abstract
Median KCCQ, patients who experienced DH vs not
66.0 vs 85.0; P = 0.002
Median KCCQ, patients who experienced DP vs not
53.5 vs 85.0; P = 0.001
Patients scoring ≤50 had significantly worse event-free survival
P = 0.004 for DH; P = 0.001 for DP
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Median KCCQ by anatomic complexity | great complexity median 76.6 · simple/moderate complexity median 89.0 |
| Median KCCQ by ACHD physiological stage | D median 72.6 · A median 98.0 |
| Median KCCQ by physician-reported HF | physician-reported HF median 72.2 · without HF median 87.2 |
| Median KCCQ by NYHA functional class | NYHA III median 44.4 · NYHA I median 96.5 |
- Median KCCQ by anatomic complexity — P
- P = 0.015
- Median KCCQ by ACHD physiological stage — P
- P < 0.001
- Median KCCQ by physician-reported heart failure (HF) — P
- P < 0.001
- Median KCCQ by NYHA functional class — P
- P < 0.001
Original publication
Construct and Predictive Validity of the Kansas City Cardiomyopathy Questionnaire in Adult Congenital Heart Disease. JACC Adv. Published 24 July 2025. doi:10.
Summarised from the published abstract; every number is checked against it