Heart failure & cardiomyopathies
Is Vascular Remodelling in Patients with Chronic Heart Failure Exaggerated?
Authors' conclusion
In CHF+ patients we observed augmented vascular remodelling and functional impairment compared with CHF- patients independently of cardiovascular risk factors, age, and gender, and the extent of vascular remodelling and impairment was related to the severity of CHF.
Study context
- Population
- Patients with chronic heart failure and subjects without chronic heart failure (CHF)
- Participants
- 105 vs 118
- Exposure
- CHF with EF ≤49% vs no CHF
- CHF+n = 105
- CHF (CHF-)n = 118reference
- Outcome
- Vascular remodelling and function under laboratory and 24-h ambulatory conditions
Methodological detailsmonocentric, observational
- Monocentric
- Observational
Main finding
As reported in the abstract
- CHF+ vs CHF-: P = 0.010
- CHF+ vs CHF-: P = 0.011
- CHF+ vs CHF-: P = <0.001
- CHF+ vs CHF-: P = <0.001
- CHF+ vs CHF-: P = 0.002
- CHF+ vs CHF-: P = 0.022
- Adjusted for age, gender, arterial hypertension, hyperlipidaemia, T2DM, obesity and smoking
Observational data: associations, not effects.
Further findings
Correlation of NT-proBNP with vascular parameters (CHF+)
- Higher pulse wave velocity (PWV)
- r = 0.340, P = <0.001
- Higher central SBP
- r = 0.292, P = 0.005
- Trend to higher central pulse pressure
- r = 0.198, P = 0.058
- Higher 24-h brachial PP
- r = 0.322, P = 0.002
- 24-h total peripheral resistance
- s = 0.227, P = 0.041
- After full adjustment for covariates
Original publication
Is Vascular Remodelling in Patients with Chronic Heart Failure Exaggerated? ESC Heart Fail. Published 3 October 2022. doi:10.
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