Atherosclerosis quantification and cardiovascular risk: the ISCHEMIA trial
Authors' conclusion
In ISCHEMIA, total plaque volume was associated with cardiovascular death or myocardial infarction. In this highly diseased, high-risk population, enhanced assessment of atherosclerotic burden using AI-QCT-derived measures of plaque volume and composition modestly improved event prediction.
Study context
- Population
- ISCHEMIA participants with analysable baseline coronary CT angiography (highly diseased, high-risk population)analysable coronary computed tomography angiography (CCTA) data
- Participants
- 3,711 participants
- Primary endpoint
- Composite:
- Primary outcome of CV death
- MI
- Follow-up
- Median 3.3 (IQR 2.2-4.4) years
Primary result
As reported in the abstract
Adjusted HR per IQR increase [559 mm³] in total plaque volume
1.56
95% CI 1.25–1.97P = .001
Further findings
Predictive value: Atherosclerosis imaging quantitative computed tomography (AI-QCT) plaque quantification + baseline risk factors vs risk factors alone
AUC
| Group | AI-QCT + risk factors | Risk factors | P value |
|---|---|---|---|
| 6 months | 0.688 | 0.637 | P = 0.006 |
| 2 years | 0.660 | 0.617 | P = 0.003 |
| 4 years | 0.654 | 0.608 | P = 0.002 |
Other reported outcomes
- Findings similar for the other reported outcomes
Original publication
Atherosclerosis quantification and cardiovascular risk: the ISCHEMIA trial. Eur Heart J. Published 5 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →