Health Status and Clinical Outcomes in Older Adults With Chronic Coronary Disease: The ISCHEMIA Trial
Authors' conclusion
Older patients with chronic coronary disease and moderate or severe ischemia had consistent improvement in angina frequency but less improvement in angina-related health status with invasive management compared with younger patients. Invasive management was not associated with improved clinical outcomes in older or younger patients.
Study context
- Population
- Adults with chronic coronary disease and moderate or severe ischemia
- Participants
- 4,617 adults
- Comparison
- Invasive vs conservative management, by age
- Primary endpoint
- Angina-specific health status (7-item SAQ summary score, 0-100; higher = better) and composite of CV death, MI, or hospitalization for resuscitated cardiac arrest, unstable angina or HF, by age
- Follow-up
- 1 year (SAQ)
Primary result
As reported in the abstract
1-year SAQ summary score difference (invasive minus conservative), fully adjusted, by age
Invasive vs ConservativeDifference (95% CI)
Age 55 years
4.90(3.56–6.24)
Age 65 years
3.48(2.40–4.57)
Age 75 years
2.13(0.75–3.51)
- No age differences in invasive vs conservative effect on composite clinical outcome
- P for interaction = 0.29
Further findings
Age distribution
Age distribution
- Baseline Seattle Angina Questionnaire (SAQ) summary scores lower in participants aged <65 years
SAQ Angina Frequency improvement by age
- Improvement less dependent on age
- P for interaction = 0.08
Original publication
Health Status and Clinical Outcomes in Older Adults With Chronic Coronary Disease: The ISCHEMIA Trial. J Am Coll Cardiol. Published 2 May 2023. doi:10.
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