Ischemic Heart Disease and Vascular Risk Factors Are Associated With Accelerated Brain Aging
Authors' conclusion
Prevalent IHD and coexisting vascular risk factors are associated with accelerated brain aging and risk of dementia.
Study context
- Population
- UK Biobank participants with brain MRI
- Participants
- 1,341 vs 35,237
- Exposure
- Prevalent ischemic heart disease (IHD) vs no prevalent IHD
- IHDn = 1,341
- No IHDn = 35,237reference
- Outcome
- Brain-age delta (predicted brain age minus chronological age, years; positive = accelerated brain aging)
Methodological detailsUK Biobank, MRI-based brain-age model (Bayesian ridge regression)
- UK Biobank
- MRI-based brain-age model (Bayesian ridge regression)
Main finding
As reported in the abstract
Brain aging in prevalent IHD
- Prevalent IHD linked to significantly accelerated brain aging, not fully mediated by microvascular injury
- P < 0.001
Observational data: associations, not effects.
Further findings
Dementia risk with brain aging (positive brain-age delta)
- OR for dementia
- 1.13 [95% CI: 1.04-1.22]; P = 0.002
Brain aging and risk factors
- Brain aging associated with vascular risk factors (such as diabetes) and high adiposity
- Without IHD, brain aging associated with CV structural and functional changes of aging hearts; these not linked with dementia risk
Original publication
Ischemic Heart Disease and Vascular Risk Factors Are Associated With Accelerated Brain Aging. JACC Cardiovasc Imaging. Published 12 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →