Congenital heart diseaseRandomised controlled trial
Ivabradine Use and Exercise Capacity Post-Atrial Switch Repair for Transposition of Great Arteries
- single-center, randomized, double-blind, crossover study
Authors' conclusion
Ivabradine use in patients with transposition of the great arteries and atrial switch repair lowered peak heart rate with exercise and was associated with a higher oxygen pulse. (Effect of Ivabradine use on exercise capacity in patients with transposition of the great arteries [TGA] post atrial switch repair; ACTRN12621000196842).
Study context
- Population
- Patients with transposition of the great arteries who have undergone an atrial switch repair19 patients were eligible, 10 completed the study
- Participants
- 10 patients
- Comparison
- Ivabradine vs placebo
Primary result
Heart rate at baseline
Difference
−14.6 beats/min
CI −24 to −5
P = 0.008
By group
As reported in the abstract
Further findings
| Outcome | ivabradine | placebo | difference (beats/min) (CI) | P value | |
|---|---|---|---|---|---|
| Heart rate at peak exercise · lower with ivabradine | 131 ± 7 beats/min | 146 ± 7 beats/min | −15.3 (−24 to −6) | P = 0.003 | |
| −30−20−10010Difference, beats/min (linear scale) |
Peak oxygen consumption
difference (mL/kg/min) +1.2 (−0.09 to 2.6) · P = 0.06
Peak oxygen pulse · higher on ivabradine
difference (mL/beat) +1.7 (0.9–2.6) · P = 0.002
| Outcome | ivabradine | placebo | mean difference (CI) | P value | |
|---|---|---|---|---|---|
| Visual analog score | 73.5 ± 5.6 | 62.5 ± 5.6 | 11.0 (−1.6 to 23.6) | P = 0.08 | |
| −100102030Difference (linear scale) |
Safety
Adverse events
- symptomatic bradycardia
- One patient
- phosphenes
- one patient
Original publication
Summarised from the published abstract; every number is checked against it