Neoaortic Regurgitation Detected by Echocardiography After Arterial Switch Operation: A Systematic Review and Meta-Analysis
Authors' conclusion
The risks of NeoARD and NeoAR increase over time following ASO surgery.
Study context
- Population
- Patients after arterial switch operation (ASO) for transposition of the great arteries30 publications
- Participants
- 6,169 patients
- Outcome
- Neoaortic regurgitation (NeoAR), by severity (trace, mild, moderate, severe)
Methodological detailsrandom-effects meta-analysis
- Random-effects meta-analysis
Pooled result
As reported in the abstract
Cumulative incidence of NeoAR · 30-year follow-up
≥mild neoaortic regurgitation (NeoAR)
67.5%
≥moderate NeoAR
21.4%
Further pooled results
| Outcome | MD (95% CI) | P value | |
|---|---|---|---|
| Neoaortic Z-scores, NeoAR vs no NeoAR · last follow-up≥mild NeoARvs No NeoARAnnulus | 1.17 (0.52–1.82) | P < 0.001 | |
| Neoaortic Z-scores, NeoAR vs no NeoAR · last follow-up≥moderate NeoARvs No NeoARAnnulus | 1.38 (0.46–2.30) | P = 0.003 | |
| Neoaortic Z-scores, NeoAR vs no NeoAR · last follow-up≥mild NeoARvs No NeoARRoot | 1.83 (1.16–2.49) | P < 0.001 | |
| Neoaortic Z-scores, NeoAR vs no NeoAR · last follow-up≥moderate NeoARvs No NeoARRoot | 1.84 (1.07–2.60) | P < 0.001 | |
| −2024Difference (linear scale) |
Risk factors for any NeoAR
- Prior pulmonary artery banding, VSD, aorto-pulmonary mismatch, bicuspid pulmonary valve, NeoAR at discharge
Original publication
Neoaortic Regurgitation Detected by Echocardiography After Arterial Switch Operation: A Systematic Review and Meta-Analysis. JACC Adv. Published 7 March 2024. doi:10.
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