Heart failure & cardiomyopathies
Late gadolinium enhancement distribution patterns in non-ischaemic dilated cardiomyopathy: genotype–phenotype correlation
Authors' conclusion
LGE patterns in DCM have a specific distribution according to the affected gene. Certain LGE patterns are associated with an increased risk of MVA and with an increased yield of genetic testing.
Study context
- Population
- Patients with non-ischaemic dilated cardiomyopathy (DCM) undergoing CMRfinal cohort of 600
- Participants
- 577 patients
- Exposure
- Late gadolinium enhancement (LGE) patterns by causative gene
- Outcome
- LGE patterns according to genotype
Methodological details20 Spanish centres
- 20 Spanish centres
Main finding
As reported in the abstract
LGE presence / subepicardial LGE by gene
| Group | Value | LGE | Subepicardial LGE |
|---|---|---|---|
| TNNT2 | 0% | 0% | |
| RBM20 | 5% | 5% | |
| MYH7 | 20% | 20% | |
| DMD | 50% | 50% | |
| DSP | 41% | 41% | |
| FLNC | 18% | 18% |
Value
TNNT20%
RBM205%
MYH720%
DMD50%
DSP41%
FLNC18%
LGE
TNNT20%
RBM205%
MYH720%
DMD— not stated in the abstract
DSP— not stated in the abstract
FLNC— not stated in the abstract
Subepicardial LGE
TNNT2— not stated in the abstract
RBM20— not stated in the abstract
MYH7— not stated in the abstract
DMD50%
DSP41%
FLNC18%
- Significant differences in LGE patterns between genes
- P < 0.001
- Causative genetic variant identified
- 219 (38%)
- LGE present
- 147 (25.5%)
Observational data: associations, not effects.
Further findings
Major ventricular arrhythmias by LGE pattern
- Subepicardial, lineal midwall, transmural, RV insertion point or combined LGE patterns: increased major ventricular arrhythmias (MVA) risk vs no LGE
Genetic yield by LGE pattern
- Genetic yield differed according to LGE patterns
Original publication
Late gadolinium enhancement distribution patterns in non-ischaemic dilated cardiomyopathy: genotype–phenotype correlation. Eur Heart J Cardiovasc Imaging. Published 10 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →