Lead Longevity in Pediatric and Congenital Heart Disease Patients: The Impact of Patient Somatic Growth
Authors' conclusion
Greater patient somatic growth is an important predictor of lead failure.
Study context
- Population
- Pediatric and congenital heart disease (CHD) patients with a pacemaker or defibrillator, single large children's hospital, 30-year timespan952 leads
- Participants
- 396 participants
- Outcome
- Pacemaker and defibrillator lead survival
- Follow-up
- Beyond 10 years after implantation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Overall lead survival
Lead survival at 10 years
87%
Lead survival at 15 years
78%
Lead survival at 20 years
69%
Observational data: associations, not effects.
Further findings
Predictors of lead failure (multivariate)
| HR (95% CI) | ||
|---|---|---|
| Somatic growth ≥5 cm/yearMost significant predictor of lead failure · log-rank test for univariate associations | 3.33 (1.78–6.25) | |
| 0.10.31310Hazard ratio (log scale) |
- Predictors of lead failure (multivariate) — Male sex, younger age, greater somatic growth, LV lead location and epicardial approach associated with higher likelihood of lead failure
- P <0.05
Predictors of lead failure (multivariate)
- CHD, lead insulation and lead manufacturer had no impact on lead longevity
Original publication
Lead Longevity in Pediatric and Congenital Heart Disease Patients: The Impact of Patient Somatic Growth. JACC Clin Electrophysiol. Published 13 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →