Valvular & structural heart disease
Left and right ventricular longitudinal systolic function following aortic valve replacement in the PARTNER 2 trial and registry
Authors' conclusion
SAVR but not TAVR was associated with a marked deterioration in RV longitudinal systolic function and RV-PA coupling. Lower TAPSE and RV-PA coupling at 30 days were associated with inferior clinical outcomes at 5 years. In patients with LVEF < 50%, TAVR was associated with superior 5-year outcomes.
Study context
- Population
- Patients undergoing aortic valve replacement in the PARTNER 2 trial and registry
- Participants
- 985 vs 719
- Comparison
- Surgical AVR (SAVR) vs TAVR
- SAVRn = 985
- TAVRn = 719
Primary result
As reported in the abstract
- Tricuspid annulus plane systolic excursion (TAPSE) and RV-pulmonary artery (RV-PA) coupling decreased significantly following SAVR
- TAPSE and RV-PA coupling remained stable following TAVR
Further findings
Primary endpoint in patients with baseline LVEF <50% (subgroup) · 5 years
| HR (95% CI) | P value | ||
|---|---|---|---|
| SAVRIncreased risk with LV ejection fraction <50% at baseline | 1.34 (1.08–1.68) | P = 0.009 | |
| TAVRLV ejection fraction <50% at baseline; risk not increased | 1.12 (0.88–1.42) | ||
| 0.512Hazard ratio (log scale) |
Change in TAPSE and RV-PA coupling after aortic valve replacement (AVR) · 30 days and 1 year
- TAPSE and RV-PA coupling decreased significantly following SAVR, but remained stable following TAVR
Cardiac mortality by RV-PA coupling at 30 days
- Lower RV-PA coupling at 30 days showed the strongest association with cardiac mortality
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →