Arrhythmias & electrophysiology
Left atrial appendage angiography for stroke risk prediction in patients with atrial fibrillation
Authors' conclusion
Impaired mechanical function of the LAA, indicated by a low LAAEF and CR, is associated with a history of stroke in patients with AF.
Study context
- Population
- Patients with atrial fibrillation (AF) referred for left atrial appendage occlusion (LAAO)
- Participants
- 746 patients
- Exposure
- Stroke vs no stroke history: Left atrial appendage (LAA) mechanical function by angiography
- Stroken = 151
- Controln = 595reference
- Outcome
- Association of LAA mechanical function (left atrial appendage ejection fraction (LAAEF), contrast retention grade) by angiography with stroke
Main finding
As reported in the abstract
Grade 3 CR
P < 0.001
| Outcome | Stroke | Control | P value |
|---|---|---|---|
| LAAEF | 14% [9-19] | 20% [12-33] | P < 0.001 |
- Contrast retention (CR) grade 2 vs grade 1, independently associated with stroke (multivariable)
- 7.29; 95% CI: 2.84-21.65; p<0.001
- CR grade 3 vs grade 1, independently associated with stroke (multivariable)
- 16.45; 95% CI: 6.16-51.02; p<0.001
Observational data: associations, not effects.
Further findings
Discrimination of stroke (ROC)
- C-statistic, CR vs CHA2D-VASc score
- 0.712 vs 0.512; p<0.001
- C-statistic, CR + CHA2DS2-VASc vs CHA2DS2-VASc alone
- 0.871 vs 0.829; p=0.048
Original publication
Left atrial appendage angiography for stroke risk prediction in patients with atrial fibrillation. EuroIntervention. Published 23 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →