Arrhythmias & electrophysiology
Left atrial appendage closure device outcomes among cirrhosis patients with atrial fibrillation: a United States National Cohort Study
Authors' conclusion
Left atrial appendage occlusion procedure in patients with cirrhosis had relatively similar GI bleeding and stroke rates, however, had higher rates of 30-day readmission.
Study context
- Population
- Hospitalizations for Left Atrial Appendage Occlusion (LAAO) procedure, US Nationwide Readmissions Database, 2016–19
- Participants
- 54,897 index hospitalizations
- Exposure
- LAAO in patients with vs without cirrhosis
- Cirrhosisn = 905
- Outcome
- In-hospital clinical outcomes and 30-day readmissions
Methodological detailsNationwide Readmissions Database
- Nationwide Readmissions Database
Main finding
As reported in the abstract
30-day readmissions · 30 days
P = 0.01
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Predictors of 30-day readmission: CHA2DS2-Vasc score of sixvs other scoresMultivariate Cox regression | 2.24 (1.58–3.16) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
In-hospital outcomes associated with cirrhosis (adjusted multivariate logistic regression)
- AKI, coagulopathy, fresh frozen plasma (FFP) transfusion and blood transfusion strongly associated with cirrhosis
- Gastrointestinal (GI) bleeding, ischaemic stroke and intracranial haemorrhage not associated with cirrhosis
Safety
GI bleeding
Coagulopathy
Blood transfusion
P = 0.047
FFP transfusion
P = 0.05
- Blood transfusion: Overall 872 (1.59%)
- FFP transfusion: Overall 888 (1.62%)
Original publication
Left atrial appendage closure device outcomes among cirrhosis patients with atrial fibrillation: a United States National Cohort Study. Europace. Published 1 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →