Arrhythmias & electrophysiology
Left Atrial Appendage Closure for Patients With a History of Ischemic Stroke Despite Oral Anticoagulant
Authors' conclusion
The patients after LAAC who have had an IS despite OAC did not differ in CV death but were at higher risk of IS even after LAAC.
Study context
- Population
- Nonvalvular atrial fibrillation (AF) patients who underwent left atrial appendage closure (LAAC)
- Participants
- 1,418 patients
- Exposure
- Control vs Previous ischemic stroke (IS) despite oral anticoagulant (OAC) vs Previous IS without OAC
- Outcome
- Coprimary: CV death and IS
- Follow-up
- Median 367 days
Methodological detailsregistry (OCEAN-LAAC)
- Registry (OCEAN-LAAC)
Main finding
As reported in the abstract
Each group vs controlSubdistribution hazard ratio (95% CI)P value
Previous IS despite OACCV death
1.78(0.87–3.64)
Previous IS without OACCV death
1.45(0.59–3.55)
Previous IS despite OACIS; Gray's test
2.62(1.17–5.86)
P = 0.02Previous IS without OACIS; Gray's test
1.24(0.36–4.28)
P = 0.70Observational data: associations, not effects.
Original publication
Left Atrial Appendage Closure for Patients With a History of Ischemic Stroke Despite Oral Anticoagulant. JACC Clin Electrophysiol. Published 17 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it