Arrhythmias & electrophysiology
Left atrial appendage closure in very elderly patients in the French National Registry
Authors' conclusion
Despite a higher mean CHA2DS2-VASc score in octogenarians, the rate of thromboembolic events after LAAC in this age group was similar to that in patients aged <80 years.
Study context
- Population
- Patients with AF and contraindications to anticoagulation undergoing left atrial appendage closure (LAAC), French National Registry, 2018–2021median age 79.7 (73.6–84.3) years
- Participants
- 1,053 patients
- Exposure
- LAAC in patients ≥80 years vs <80 years
- ≥80 yearsn = 512
- Outcome
- Composite of:
- Ischaemic stroke
- Systemic embolism
- Unexplained or CV death
Methodological detailsnationwide, multicentre, 53 French cardiology centres
- Nationwide
- Multicentre
- 53 French cardiology centres
Main finding
As reported in the abstract
Primary endpoint rate overall
8.1/100 patient-years
No statistically significant difference between age groups (≥80 vs <80 years)
9.4 and 7.0/100 patient-years
p=0.19
Observational data: associations, not effects.
Further findings
Thromboembolic events, octogenarians vs <80 years
- Similar in both groups
- 3.0 vs 3.1/100 patient-years; p=0.85
- Despite higher mean CHA2DS2-VASc score in octogenarians
All-cause mortality, octogenarians vs <80 years
- Significantly higher in octogenarians
- 15.3 vs 10.1/100 patient-years, p<0.015
Non-CV deaths, octogenarians vs <80 years
- Higher rate in octogenarians
- 8.2 vs 4.9/100 patient-years, p=0.034
Safety
Procedure-related serious adverse events · non-significant
P = 0.07
Original publication
Left atrial appendage closure in very elderly patients in the French National Registry. Heart. Published 9 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →