Heart failure & cardiomyopathies
Left Atrial Roof Enlargement Is a Distinct Feature of Heart Failure With Preserved Ejection Fraction
Authors' conclusion
LA roof dilation is an early remodeling pattern in masked HFpEF advancing to overall LA enlargement in overt HFpEF. These distinct features predict the occurrence of atrial fibrillation and cardiovascular hospitalization.
Study context
- Population
- Patients with exertional dyspnea and diastolic dysfunction on echocardiography (E/e', >8)
- Participants
- 34 vs 34
- Exposure
- Heart failure with preserved ejection fraction (HFpEF) vs noncardiac dyspnea
- HFpEFn = 34
- Noncardiac dyspnean = 34reference
- Outcome
- LA 3D shape phenotype and LA HFpEF shape score
Methodological detailscomputational 3D left atrial (LA) shape models from CMR, rest and exercise-stress right heart catheterization
- Computational 3D LA shape models from CMR
- Rest and exercise-stress right heart catheterization
Main finding
As reported in the abstract
LA HFpEF shape score discriminating HFpEF from noncardiac dyspnea, AUC
0.81
Observational data: associations, not effects.
Further findings
AF occurrence, by LA HFpEF shape score
| HR (95% CI) | P value | ||
|---|---|---|---|
| LA HFpEF shape score | 1.02 (1.01–1.04) | P = 0.003 | |
| 0.512Hazard ratio (log scale) |
CV hospitalization, by LA HFpEF shape score · 24 months
| HR (95% CI) | P value | ||
|---|---|---|---|
| LA HFpEF shape score | 1.02 (1.00–1.04) | P = 0.043 | |
| 0.512Hazard ratio (log scale) |
Original publication
Left Atrial Roof Enlargement Is a Distinct Feature of Heart Failure With Preserved Ejection Fraction. Circ Cardiovasc Imaging. Published 16 July 2024. doi:10.
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