Heart failure & cardiomyopathies
Left atrioventricular ratio (left atrium (LA):Left ventricle (LV)): using left ventricular size as the reference for identifying maladaptive left atrial remodelling
Authors' conclusion
The LA:LV ratio effectively discriminates between adaptive and maladaptive atrial remodelling. LA:LV is typically ∼0.5. Lower ratios correlate with higher functional capacity and physiological remodelling, whereas ratios ≥0.75 may indicate pathological remodelling and warrant consideration of atrial pathology.
Study context
- Population
- Adults spanning the cardiorespiratory fitness spectrum, healthy and with pathology, assessed by echocardiography and VO2peak
- Participants
- 2,943 adults
- Exposure
- LA:LV in pathology vs healthy adults, and across VO2 peak quartiles in healthy participants
- Healthyn = 1,600
- Pathologyn = 1,343
- Outcome
- LA:LV
Main finding
As reported in the abstract
Healthy
0.49
median · IQR 0.38–0.61
Pathology
0.53
range as printed 0.38–0.75
P < 0.001
- AF
- 0.60 (0.45-0.78)
- HFpEF
- 0.70 (0.51-0.88)
- Increase vs. healthy adults
- 30%
Observational data: associations, not effects.
Further findings
Indexed LA volume and LA:LV by VO2 peak quartile
- Highest indexed LA volumes, Q4
- 36 (28-46) mL/m²
- LA:LV highest in Q1
- 0.53 (0.42-0.69)
Concordance of elevated LAVi (≥34 mL/m²) with elevated LA:LV ratio (≥0.75)
- Q1-Q2
- ∼60%
- Q4
- 7%
Original publication
Left atrioventricular ratio (LA:LV): using left ventricular size as the reference for identifying maladaptive left atrial remodelling. Eur Heart J Cardiovasc Imaging. Published 27 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →