Heart failure & cardiomyopathies
Left bundle branch pacing vs left ventricular septal pacing in the same patients with heart failure and left bundle branch block
Authors' conclusion
In this pilot study of patients with HF and LBBB, both LBBP and LVSP significantly improved left ventricular hemodynamics and mechanical synchrony without compromising RV function. LBBP potentially has superior left ventricular hemodynamic effects to LVSP.
Study context
- Population
- Patients with reduced left ventricular ejection fraction (LVEF) and typical complete left bundle branch block (LBBB) who received cardiac resynchronization therapy pacing (CRTP) implantation
- Participants
- 14 patients
- Comparison
- Compare the differences in LBBB mode, left bundle branch pacing (LBBP) mode, and left ventricular septal pacing (LVSP) mode within the same patients undergoing CRTP
- Outcome
- QRS duration (QRSd) and left ventricular activation time (LVAT)
Methodological detailswithin-patient comparison
- Within-patient comparison
Main finding
As reported in the abstract
- Both pacing modes significantly reduced QRS duration (QRSd) and left ventricular activation time (LVAT) versus LBBB
- all P<0.001
- LVSP yielding wider QRSd than LBBP
- P<0.001
Further findings
LV mechanical synchrony parameter (SDI)
- LBBP showed better performance than LVSP, and both pacing modes were superior to LBBB condition
- all P < 0.001
LVEF
- LVEF increased significantly with both pacing modes, with a greater increase observed in LBBP compared to LVSP
Right ventricular function
- No significant differences among the three modes
Original publication
Left bundle branch pacing vs left ventricular septal pacing in the same patients with heart failure and left bundle branch block. Heart Rhythm. Published 27 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →