Heart failure & cardiomyopathies
Left Bundle Branch Pacing vs Left Ventricular Septal Pacing vs Biventricular Pacing for Cardiac Resynchronization Therapy
Authors' conclusion
In patients undergoing CRT, LBBP was associated with improved outcomes compared with LVSP and BIVP, while outcomes between BIVP and LVSP are similar.
Study context
- Population
- Patients undergoing CRT
- Participants
- 415 patients
- Exposure
- Left bundle branch pacing (LBBP) vs left ventricular septal pacing (LVSP) vs BIVP for CRT
- LBBPn = 141
- LVSPn = 31
- BIVPn = 243reference
- Outcome
- Freedom from heart failure (HF)-related hospitalization and all-cause mortality (composite)
- Follow-up
- Median 399 days (Q1-Q3: 249.5-554.8 days)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Freedom from primary composite outcome
Hazard ratio (95% CI)P value
LBBPvs BIVP
1.43(1.175–1.730)
P < 0.001- LBBP vs LVSP
- HR 1.37 (95% CI 1.143–1.649); P = 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | LBBP | LVSP | HR (95% CI) | P value |
|---|---|---|---|---|
| Freedom from HF-related hospitalizationLBBP vs LVSP · 31.4% absolute increase | 83% | 51.6% | 3.55 (1.856–6.791) | P < 0.001 |
All-cause mortality
- No differences in all-cause mortality (LBBP vs LVSP)
Original publication
Left Bundle Branch Pacing vs Left Ventricular Septal Pacing vs Biventricular Pacing for Cardiac Resynchronization Therapy. JACC Clin Electrophysiol. Published 20 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →