Heart failure & cardiomyopathies
Prognostic Impact of Repeated NT-proBNP Measurements in Patients With Heart Failure With Reduced Ejection Fraction
Authors' conclusion
Repeated NT-proBNP measurements are a strong predictor of outcomes in heart failure with reduced ejection fraction with an increase in concentration occurring well before event onset.
Study context
- Population
- Outpatients with chronic HFrEF, US and Canada
- Participants
- 894 outpatients
- Comparison
- Repeated vs single NT-proBNP measurements for prognosis
- Primary endpoint
- CV death or HF hospitalization
- Follow-up
- 2-year study period
Methodological detailsjoint longitudinal and survival model, 45 outpatient sites
- Joint longitudinal and survival model
- 45 outpatient sites
Primary result
As reported in the abstract
- Baseline NT-proBNP, per doubling: adjusted HR 1.17 (95% CI 1.08-1.28)
- P = 0.0003
- Serial NT-proBNP measurements: adjusted HR 1.66 (95% CI 1.50-1.84)
- P < 0.0001
Further findings
Secondary trial endpoints
- Similar increased risk with serial measurements
Timing of NT-proBNP rise (joint modelling)
- Increase in NT-proBNP occurred weeks before onset of adjudicated events
Original publication
Prognostic Impact of Repeated NT-proBNP Measurements in Patients With Heart Failure With Reduced Ejection Fraction. JACC Heart Fail. Published 20 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →