Valvular & structural heart disease
Left-sided heart failure determines outcomes in patients with severe tricuspid regurgitation undergoing percutaneous repair
Authors' conclusion
Consideration of left-sided pathologies in patients with significant TR is important as outcomes and predictors for survival differ. Across HF phenotypes, procedural success is associated with survival but the prognostic impact of TR reduction may unfold over time especially in HFpEF.
Study context
- Population
- Patients with severe tricuspid regurgitation (TR) undergoing tricuspid transcatheter edge-to-edge repair (T-TEER)
- Participants
- 1,773 patients
- Exposure
- Heart failure (HF) phenotypes after T-TEER
- Outcome
- All-cause mortality
- Follow-up
- 2 years
Methodological detailsEuroTR registry
- EuroTR registry
Main finding
As reported in the abstract
Estimated 2-year mortality
Observational data: associations, not effects.
Further findings
| Outcome | HFmrEF/HFrEF | Non-overt left-sided HF |
|---|---|---|
| Procedural success (TR ≤moderate) | 78% | 87% |
- Procedural success (TR ≤moderate): highest in non-overt left-sided HF, lowest in HFmrEF/HFrEF; HFpEF value not printed
Symptom burden
- Improved across all groups
- P < 0.001
Procedural success and outcomes
- Procedural success associated with improved outcomes in all groups
- P < 0.01
Survival among successfully treated patients, HFpEF vs HFmrEF/HFrEF
- Comparable at 1 year; better in HFpEF at 2 years
- P = 0.027
Predictors of survival by phenotype
- HFmrEF/HFrEF: RV function; HFpEF: right-sided pressures; non-overt left-sided HF: baseline TR severity
Original publication
Left-sided heart failure determines outcomes in patients with severe tricuspid regurgitation undergoing percutaneous repair. Eur J Heart Fail. Published 14 March 2026. doi:10.
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