Valvular & structural heart disease
Invasive Hemodynamics and Risk Stratification in T-TEER: Moving Beyond ESC Thresholds - EuroTR Registry Insights
Authors' conclusion
In patients undergoing transcatheter tricuspid valve edge-to-edge repair, invasive hemodynamics-especially elevated PCWP-are independently associated with early patient-centered outcomes and late adverse clinical events. Despite overall improvement of the functional status and no impact on residual tricuspid regurgitation, patients with higher mean pulmonary artery pressure or PCWP benefit less.
Study context
- Population
- Patients with invasive haemodynamic data undergoing isolated transcatheter tricuspid valve edge-to-edge repair for significant tricuspid regurgitation
- Participants
- 711 patients
- Comparison
- Invasive haemodynamic parameters and outcomes after T-TEER
- Primary endpoint
- Composite of all-cause death or HF hospitalisation (HFH) at 2 years; patient-centered composite of all-cause mortality, HFH, NYHA class IV/worsening NYHA class at 6 months
- Follow-up
- 2 years; 6 months
Methodological detailsmulticentre, registry subanalysis
- Multicentre
- Registry subanalysis
Primary result
As reported in the abstract
PCWP≥20 mm HgHazard ratio (95% CI)P value
Early clinical deterioration (6-month patient-centered composite); independent association
2.77(1.47–5.28)
P < 0.0012-year death/HFH; independent association
1.75(1.03–3.02)
P = 0.04- 2-year survival free from death and HFH
- 63%
- Early patient-centered composite outcome
- 25%
Secondary outcomes
Residual tricuspid regurgitation ≥3+
- No invasive parameter was associated with residual TR ≥3+
NYHA class improvement
- NYHA class improved significantly throughout follow-up
- P < 0.001
- Less symptomatic benefit with elevated mPAP
- P = 0.04
- Less symptomatic benefit with elevated pulmonary capillary wedge pressure (PCWP)
- P < 0.01
Original publication
Invasive Hemodynamics and Risk Stratification in T-TEER: Moving Beyond ESC Thresholds - EuroTR Registry Insights. Circ Cardiovasc Interv. Published 14 November 2025. doi:10.
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