Arrhythmias & electrophysiology
Left Ventricular Late Gadolinium Enhancement for Arrhythmic Risk Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
Authors' conclusion
While associated with the risk of VA in ARVC, LV LGE did not provide incremental prognostic value for incident VA risk prediction compared with the ARVC risk calculator.
Study context
- Population
- Patients with definite ARVC, no prior sustained ventricular arrhythmia (VA), and contrast-enhanced cardiac magnetic resonance at baseline132 (34.3%) had left ventricular (LV) late gadolinium enhancement (LGE), 98 (25.5%) high-risk pattern
- Participants
- 385 patients
- Comparison
- Incremental prognostic value of LV LGE on the risk calculator
- LV LGEn = 132
- High-risk LV LGEn = 98
- Outcome
- Sustained VA
- Follow-up
- 3.1 [1.2-5.8] years
Methodological details17 centers, Cox proportional hazard models, sensitivity analysis of high-risk LGE
- 17 centers
- Cox proportional hazard models
- Sensitivity analysis of high-risk LGE
Main finding
As reported in the abstract
Patients experienced VA
67
17.4%
Further findings
| Outcome | Hazard ratio | P value |
|---|---|---|
| VA, univariable analysisLV LGE · higher risk for VA | 1.82 | P = 0.014 |
| VA, univariable analysisHigh-risk LV LGE · higher risk for VA | 1.85 | P = 0.017 |
Sustained VA, adjusted for ARVC calculator-estimated risk
- LV LGE did not independently predict sustained VA
- P = 0.85
- High-risk LV LGE did not independently predict sustained VA
- P = 0.87
Original publication
Left Ventricular Late Gadolinium Enhancement for Arrhythmic Risk Prediction in ARVC. Circ Arrhythm Electrophysiol. Published 29 January 2026. doi:10.
Summarised from the published abstract; every number is checked against it