Heart failure & cardiomyopathies
Left ventricular recovery and outcomes in patients with a durable left ventricular assist device: the EUROMACS registry
Authors' conclusion
This multicentre European study shows that LV recovery mostly occurs within the first year after LVAD implantation and is associated with better clinical outcomes.
Study context
- Population
- Patients with a durable left ventricular assist device (LVAD) with left ventricular ejection fraction (LVEF) measured at baseline and after implantation (EUROMACS registry)
- Participants
- 1,550 patients
- Exposure
- No recovery vs Mild vs Intermediate vs Full
- Outcome
- Prevalence, predictors and clinical impact of LV recovery after LVAD implantation
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Marginal probability of LV recovery category · 4 years
Observational data: associations, not effects.
Further findings
Predictors of any left ventricular (LV) recovery
| HR (95% CI) | ||
|---|---|---|
| Renin-angiotensin system inhibitor use | 1.17 (1.00–1.37) | |
| 0.512Hazard ratio (log scale) |
| Outcome | HR (95% CrI) | |
|---|---|---|
| All-cause mortality per 10% higher LVEF during follow-upCrI | .86 (.75-.98) | |
| 0.512Hazard ratio (log scale) |
| Outcome | HR |
|---|---|
| Predictors of any LV recoveryINTERMACS Class 2 vs INTERMACS Class 1 | .72 |
| Predictors of any LV recoveryINTERMACS Class 3 vs INTERMACS Class 1 | .64 |
| Predictors of any LV recoveryINTERMACS Class 4 vs INTERMACS Class 1 | .51 |
- All-cause mortality per 10% higher LVEF during follow-up: 95% credible interval
MACE (CV death, late right HF, arrhythmia) beyond the first year, by LV recovery category at 1 year
- Cumulative incidence lower across higher LV recovery categories (Gray's test)
- P = 0.042
Original publication
Left ventricular recovery and outcomes in patients with a durable left ventricular assist device: the EUROMACS registry. Eur Heart J. Published 9 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →