Heart failure & cardiomyopathies
Recovery From Heart Failure: Microvascular Mechanisms
Authors' conclusion
HF recovery involves reduced fibrosis and enhanced microvascularization, partly driven by fibroblast-to-endothelial cell fate transition.
Study context
- Population
- Patients with heart failure (HF) undergoing left ventricular assist device (LVAD) implantation and explantation; murine model of HF recovery
- Comparison
- Post-LVAD vs pre-LVAD myocardium
Main finding
As reported in the abstract
- Post-LVAD tissue: reduced fibrosis and increased capillary density vs pre-LVAD
- Fibroblast abundance inversely correlated with endothelial cell abundance
- Single-nucleus RNA sequencing: fibroblast subset predisposed to mesenchymal-to-endothelial transition
- Pre-LVAD nonmyocytes proliferated poorly, no vascular structures; post-LVAD nonmyocytes greater proliferation and angiogenesis, vessel-like structures
- c-Myc knockdown shifted post-LVAD nonmyocytes to pre-LVAD-like state; c-Myc overexpression induced post-LVAD-like phenotype in pre-LVAD cells
- Murine HF recovery model: increased microvascular perfusion with fibroblast-to-endothelial transition by lineage tracing
Original publication
Recovery From Heart Failure: Microvascular Mechanisms. Circulation. Published 25 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →