Heart failure & cardiomyopathies
Left Ventricular Transthyretin Amyloid Load and Apical Sparing in Patients with Newly Confirmed Transthyretin Amyloid Cardiomyopathy
Authors' conclusion
Apical sparing reflects advanced myocardial involvement in ATTR-CM and correlates with increased amyloid load and biomarkers in a large endomyocardial biopsy collective.
Study context
- Population
- Patients with newly diagnosed, biopsy-confirmed wild-type ATTR-CM61 enrolled
- Participants
- 56 patients
- Exposure
- Relative apical sparing (RELAPS) vs no RELAPS
- Outcome
- Association of apical sparing (RELAPS) with LV amyloid load on endomyocardial biopsy and clinical phenotype
Methodological detailsendomyocardial biopsy
- Endomyocardial biopsy
Main finding
As reported in the abstract
LV amyloid load
- Significantly higher left ventricular (LV) amyloid load with RELAPS than without
Observational data: associations, not effects.
Further findings
Clinical, laboratory and imaging features
- RELAPS associated with elevated NT-proBNP, higher Perugini scores, lower global longitudinal strain (GLS) and atrial strain
- No differences in age or wall thickness
Perugini score vs histological amyloid content
- Perugini scores failed to distinguish intermediate myocardial amyloid content
- 71.1%
Original publication
Left Ventricular Transthyretin Amyloid Load and Apical Sparing in Patients with Newly Confirmed Transthyretin Amyloid Cardiomyopathy. Eur J Heart Fail. Published 30 October 2025. doi:10.
Summarised from the published abstract; every number is checked against it