Heart failure & cardiomyopathies
Left ventricular volume as a predictor of exercise capacity and functional independence in individuals with normal ejection fraction
Authors' conclusion
Small resting ventricular size is associated with a higher probability of low CRF and functional disability. LV size is the strongest independent echocardiographic predictor of CRF across the health-disease continuum.
Study context
- Population
- Individuals with LVEF ≥50% undergoing echocardiography and cardiopulmonary exercise testing
- Participants
- 2,876 individuals
- Exposure
- LVEDV vs other echocardiographic measures as predictors of low cardiorespiratory fitness (CRF)
- Endurance athletesn = 309
- Healthy non-athletesn = 251
- Unexplained dyspnean = 1,969
- HFpEFn = 347
- Outcome
- Low CRF and functional disability (peak VO2 <1100ml/min or <18 ml/kg/min)
Methodological detailsmulticentre, international
- Multicentre
- International
Main finding
As reported in the abstract
- LVEDV univariable association with peak VO2: R2
- 0.45
- LVEDV univariable association with peak VO2: stdβ
- 0.67, p<0.001
- LVEDV independent predictor of peak VO2 adjusted for age, sex and BMI: stdβ
- 0.30, p<0.001
- LVEDV AUC for low CRF
- 0.72
- LVEDVi AUC for low CRF
- 0.71
- Optimal LVEDV cut-point
- 88ml
- Optimal LVEDVi cut-point
- 57ml/m²
Observational data: associations, not effects.
Original publication
Left ventricular volume as a predictor of exercise capacity and functional independence in individuals with normal ejection fraction. Eur J Prev Cardiol. Published 4 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →