Cohort study
Life’s essential 8 and progression of cardiometabolic multimorbidity trajectory: a prospective study of UK biobank
- Prospective cohort study
- multi-state model
Authors' conclusion
This study revealed that LE8 may influence the progression of CMM trajectory.
Study context
- Population
- UK Biobank participants free of cardiometabolic diseases at baseline (median age 57 years)
- Participants
- 240,346 participants
- Exposure
- High vs low cardiovascular health (CVH) by LE8 score
- Outcome
- Transitions along the CMM trajectory (health → first cardiometabolic disease → CMM [≥2 of T2D, ischemic heart disease, stroke] → death)
- Follow-up
- Median 14.01 years
Main finding
As reported in the abstract
Transitions along the CMM trajectory (multi-state model)
High CVH vs Low CVHAdjusted hazard ratio (CI)
health to FCMD
0.22(0.20–0.23)
health to death
0.23(0.21–0.25)
HR
- Similar association, first cardiometabolic disease (FCMD) to cardiometabolic multimorbidity (CMM)
- 0.41 (95% CI 0.34-0.50)
- Similar association, FCMD to death
- 0.82 (95% CI 0.68-0.98)
Observational data: associations, not effects.
Further findings
Disease-specific transitions
- CVH levels affected disease-specific transitions except stroke → death, T2D → death and CMM → death
Original publication
Life’s essential 8 and progression of cardiometabolic multimorbidity trajectory: a prospective study of UK biobank. Eur J Prev Cardiol. Published 26 April 2025. doi:10.1093/eurjpc/zwaf247
Summarised from the published abstract; every number is checked against it