Aortic & peripheral vascular disease
Global, regional, and national perspectives on aortic aneurysm burden from 1992 to 2021: temporal patterns and age-period-cohort analyses
Authors' conclusion
There is a downward trend in the global burden of AA from 1992 to 2021, with significant disparities observed across genders, age groups, and SDI regions.
Study context
- Population
- Aortic aneurysm burden in 204 countries, 1992–2021204 countries
- Outcome
- Age-standardized mortality rate (ASMR) and DALY rate (ASDR) for aortic aneurysm
- Follow-up
- 1992 to 2021
Methodological detailsGlobal Burden of Disease (GBD) 2021 data, Joinpoint regression, age-period-cohort modeling, 204 countries
- GBD 2021 data
- Joinpoint regression
- Age-period-cohort modeling
- 204 countries
Main finding
As reported in the abstract
Global ASMR for Aortic aneurysm (AA)
Age-standardized mortality rates (ASMR) in 1992
2.57 per 100,000
95% UI 2.37, 2.72
ASMR in 2021
1.86 per 100,000
95% UI 1.67, 2.00
EAPC
−1.36%
Observational data: associations, not effects.
Further findings
Age, period and cohort effects
- Age-specific mortality rate sharply escalates with age; opposite trends in period and cohort effects
Burden by sex and Socio-demographic Index (SDI)
- Consistently higher burden in males, with more pronounced reductions in high-SDI regions
Cross-country inequalities · over time
- Absolute inequality (Slope Index of Inequality (SII)) widened
- 74.4 to 84.1
- Relative inequality (Concentration Index) reduced
- 0.48 to 0.28
Original publication
Global, regional, and national perspectives on aortic aneurysm burden from 1992 to 2021: temporal patterns and age-period-cohort analyses. Eur J Prev Cardiol. Published 25 April 2025. doi:10.
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