Life's Essential 8 and the risk of cardiovascular disease: a systematic review and meta-analysis
Pooled result · CVDResult — go to the resultHazard ratio 0.47 95% CI 0.39–0.56Authors' conclusion
LE8 has a strong inverse association with CVD risk and mortality, with higher LE8 scores corresponding to significantly lower risk levels.
Study context
- Population
- Adults aged 18–80 years
- Participants
- 1,786,664 adults34 observational studies
- Comparison
- Higher vs lower LE8 scores
- Outcome
- Cardiovascular disease (CVD)
Methodological detailsrandom effects model, Searched PubMed, Google Scholar, Cochrane Library and ScienceDirect, January 2022 to June 2024
- Random effects model
- Searched PubMed, Google Scholar, Cochrane Library and ScienceDirect, January 2022 to June 2024
Pooled result
As reported in the abstract
Hazard ratio
0.47
95% CI 0.39–0.56
P < 0.00001
Higher LE8vs Lower LE8
HR 0.47 (95% CI 0.39–0.56); P < 0.00001
Further pooled results
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality | 0.54 (0.43–0.69) | P < 0.00001 | |
| CVD-related mortality | 0.37 (0.26–0.52) | P < 0.00001 | |
| 0.20.5125Hazard ratio (log scale) |
CHD and stroke
- High LE8: lower risk of CHD
- 56%
- High LE8: lower risk of stroke
- 48%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Life's Essential 8 and the risk of cardiovascular disease: a systematic review and meta-analysis. Eur J Prev Cardiol. Published 22 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →