Childhood Maltreatment and Cardiovascular Health: Role of Sex and Life's Essential 8 in the U.K. Biobank
Authors' conclusion
The impact of early-life adversities can be offset by adopting good lifelong lifestyle practices. This study underscores the need to identify individuals, particularly women, with experiences of cumulative CM events and support interventions to improve their opportunity, capability, and motivation to enhance LE8.
Study context
- Population
- Participants aged ≥40 years at baseline in the U.K. Biobank
- Participants
- 153,399 participants
- Comparison
- Compared to individuals with no childhood maltreatment (CM) exposure and low LE8 scores
- Outcome
- LE8 scores by cumulative CM exposure
Main finding
As reported in the abstract
β1CM
−0.58, 95% CI: −0.72 to −0.44
β2CM
−1.17, 95% CI: −1.36 to −0.97
β≥3CM
−2.26, 95% CI: −2.47 to −2.05
Further findings
All cardiovascular disease (CVD) events, moderate-to-high LE8 scores vs no CM exposure and low LE8 scores
- Substantial reduction in risk for all CVD events, regardless of the number of CM events experienced
Myocardial infarction among participants with low total LE8 scores, by sex
- Women appeared more vulnerable than men to myocardial infarction when exposed to cumulative CM events
Original publication
Childhood Maltreatment and Cardiovascular Health: Role of Sex and Life's Essential 8 in the U.K. Biobank. JACC Adv. Published January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →