Cardio-oncology & otherCohort study
Life’s Simple 7 score and cardiovascular health in cancer survivors: the Moli-sani study
- Prospective cohort study
Authors' conclusion
The LS7 metric, originally developed for cardiovascular health, is associated with lower all-cause and cancer mortality in cancer survivors, potentially through shared biological mechanisms.
Study context
- Population
- Cancer survivors in the Moli-sani studyMoli-sani n = 24,325
- Participants
- 779 survivors
- Exposure
- Ideal vs poor cardiovascular health
- Outcome
- All-cause mortality
- Follow-up
- Median 14.6 years
Main finding
As reported in the abstract
Hazard ratio
.62
95% CI .41-.94
Observational data: associations, not effects.
Further findings
All-cause mortality, ideal vs poor CV health, cancer-free participants
- Similar findings in cancer-free participants: HR
- .68; 95% CI .59-.78
Cancer mortality, per 1-unit increase in LS7 metric
- Each 1-unit increase in LS7 linked to lower cancer mortality: HR
- .90; 95% CI .82-.98
Mortality with Mediterranean diet score replacing the LS7 dietary component
- Cardiovascular disease (CVD) mortality: HR
- .84; 95% CI .71-1.00
- Cancer mortality: HR
- .90; 95% CI .83-.98
- Non-CVD/non-cancer mortality: HR
- .83; 95% CI .70-.98
Mediation of the LS7–mortality associations
- Inflammation, heart rate and serum vitamin D together accounted for
- over 50%
Original publication
Life’s Simple 7 score and cardiovascular health in cancer survivors: the Moli-sani study. Eur Heart J. Published 16 December 2025. doi:10.1093/eurheartj/ehaf838
Summarised from the published abstract; every number is checked against it