Aortic & peripheral vascular diseaseCohort study
Lifetime risk of lower extremity peripheral arterial disease: a Danish nationwide longitudinal study
- Nationwide cohort study
- longitudinal
Authors' conclusion
More than one in 10 Danish individuals are diagnosed with symptomatic PAD during their lifetime. Peripheral arterial disease diagnosis is associated with high morbidity and mortality at 1 and 5 years.
Study context
- Population
- Individuals in Denmark aged 40–99 years, 1998–2018151,846 diagnosed with peripheral arterial disease (PAD)
- Participants
- 4,275,631 individuals
- Exposure
- Males vs Females
- Outcome
- Lifetime risk of PAD (death as competing risk)
- Follow-up
- From age 40
Main finding
As reported in the abstract
Lifetime risk of PAD from age 40
- Overall lifetime risk of PAD from age 40
- 11.6% (95% CI 11.6%-11.7%)
- Lifetime risk in 1998-2002
- 12.9%
- Lifetime risk in 2013-18
- 10.7%
Observational data: associations, not effects.
Further findings
| Outcome | risk difference (95% CI) | |
|---|---|---|
| Lifetime risk of PAD by socioeconomic status — Lower educational level vs Females | 3.4% (3.2%–3.6%) | |
| Lifetime risk of PAD by socioeconomic status — Lower income vs Females | 0.4% (0.2%–0.5%) | |
| −2024Difference (linear scale) |
Median age at PAD diagnosis
- Median age at diagnosis 71.5 years (IQR 63.1-79.2)
Outcomes after PAD diagnosis · 1 and 5 years
- Lower limb revascularization at 1 year
- 21.4%
- Major amputation at 1 year
- 8.0%
- Death at 1 year
- 16.2%
- Lower limb revascularization at 5 years
- 26.4%
- Major amputation at 5 years
- 10.8%
- Death at 5 years
- 40.8%
- Revascularization risk varied little by sex and socioeconomic status; strong socioeconomic gradient for major amputation and all-cause death
Original publication
Lifetime risk of lower extremity peripheral arterial disease: a Danish nationwide longitudinal study. Eur Heart J. Published 17 December 2024. doi:10.1093/eurheartj/ehae867
Summarised from the published abstract; every number is checked against it