Aortic & peripheral vascular diseaseCohort study
Mosaic Loss of Y Chromosome and Risks of Peripheral Arterial and Aortic Diseases
- Cohort study
- UK Biobank
- multivariable Cox proportional hazard models
Authors' conclusion
mLOY is a novel PAAD-related risk factor. Individuals with mLOY are strongly advised to avoid or quit smoking to reduce the risk of PAAD.
Study context
- Population
- Males from the UK Biobank with available genotyping datamLOY: n = 43,458 [20.1%]
- Participants
- 216,086 males
- Exposure
- association of mLOY with incident peripheral arterial disease (PAD) and aortic aneurysm and dissection (AAD)
- mLOYn = 43,458
Main finding
Incident PAD · median follow-up 13.7 years (IQR: 12.9-14.5)
Adjusted hazard ratio
1.17
95% CI 1.10–1.24
mLOY vs no mLOY
adjusted HR 1.17 (95% CI 1.10–1.24)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | adjusted HR (95% CI) | |
|---|---|---|
| Abdominal aortic aneurysm (AAA) · median follow-up 13.7 years (IQR: 12.9-14.5) · higher risk with mLOY | 1.26 (1.14–1.38) | |
| 0.512Adjusted hazard ratio (log scale) |
PAD and abdominal aortic aneurysm (AAA) by smoking status (interaction)
- P for multiplicative interaction
- <0.001
- Smoking status and mLOY synergistically increased the risk of both PAD and AAA; P for additive interaction
- <0.05
- mLOY not significantly associated with increased risks of PAD or AAA among never-smokers; associations most pronounced in former smokers
Original publication
Mosaic Loss of Y Chromosome and Risks of Peripheral Arterial and Aortic Diseases. JACC Adv. Published 8 August 2026. doi:10.1016/j.jacadv.2026.103113
Summarised from the published abstract; every number is checked against it