Arrhythmias & electrophysiology
Lipomatous Metaplasia Facilitates Slow Conduction in Critical Ventricular Tachycardia Corridors Within Postinfarct Myocardium
Authors' conclusion
The association of myocardial LM with VT circuitry is at least partially mediated by slowing nearby corridor CV thus facilitating an excitable gap that enables circuit re-entry.
Study context
- Population
- Post-infarct patients from the prospective INFINITY study
- Comparison
- Lipomatous metaplasia (LM) vs scar; critical ventricular tachycardia (VT) corridors vs noncritical corridors distant from LM
- Critical corridorsn = 94
- Noncritical corridorsn = 115reference
- Outcome
- Impulse conduction velocity (CV) in putative VT corridors traversing the infarct zone
Methodological detailsprospective, Scar, border zone and corridors defined by late gadolinium enhancement cardiac magnetic resonance (LGE-CMR); LM by CT; images registered to electroanatomic maps; Conduction velocity (CV) at each point = mean CV to 5 adjacent points along activation wave front
- Prospective
- Scar, border zone and corridors defined by LGE-CMR; LM by CT; images registered to electroanatomic maps; CV at each point = mean CV to 5 adjacent points along activation wave front
Main finding
As reported in the abstract
CV
LM vs Scar: P < 0.001 · Critical corridors vs Noncritical corridors: P < 0.001
- Critical corridors traversing through or near LM
- 93 of 94
Further findings
| Outcome | Critical corridors | Noncritical corridors |
|---|---|---|
| CV patterns | ||
| Low-peripheral, high-center (mountain shaped) | 23.3% | — not stated in the abstract |
| Mean low-level | 46.7% | — not stated in the abstract |
| High-peripheral, low-center (valley shaped) | — not stated in the abstract | 19.1% |
| Mean high-level | — not stated in the abstract | 60.9% |
— not stated in the abstract
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Lipomatous Metaplasia Facilitates Slow Conduction in Critical Ventricular Tachycardia Corridors Within Postinfarct Myocardium. JACC Clin Electrophysiol. Published 24 May 2023. doi:10.
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