Arrhythmias & electrophysiology
Lipomatous Metaplasia Facilitates Ventricular Tachycardia in Patients With Nonischemic Cardiomyopathy
Authors' conclusion
VT circuitry corridors in NICM are more likely to traverse LM and exhibit reduced current amplitude variation compared with bystander corridors.
Study context
- Population
- Patients with nonischemic cardiomyopathy (NICM) and ventricular tachycardia (VT) (INFINITY Study); corridors computed from LGE CMR, lipomatous metaplasia (LM) distinguished by CT49 patients with NICM
- Participants
- 35 vs 151
- Comparison
- VT corridors vs non-VT corridors
- VT corridorsn = 35
- Non-VT corridorsn = 151reference
- Outcome
- Volume of LM traversed by corridors; SD of current amplitude along corridors
Methodological detailsprospective, 2-center
- Prospective
- 2-center
Main finding
As reported in the abstract
LM volume traversed
P < 0.001
Further findings
SD of current amplitude along corridors (corridors with computable current amplitude) · 28 VT vs 71 non-VT corridors
P < 0.001
VT circuit sites colocalized with LM
- Individual VT circuit sites highly colocalized with LM
- 95 out 118
Original publication
Lipomatous Metaplasia Facilitates Ventricular Tachycardia in Patients With Nonischemic Cardiomyopathy. JACC Clin Electrophysiol. Published 9 October 2024. doi:10.
Summarised from the published abstract; every number is checked against it