Prevention & lipidsCohort study
Lipoprotein(a) and Atherosclerotic Cardiovascular Disease Among Adults Aged 20 to 100 Years
- Prospective cohort study
- age- and sex-stratified analysis
Authors' conclusion
In a contemporary primary prevention cohort, the relative risk increase of ASCVD with higher lipoprotein(a) levels was similar for individuals aged older (aged 70-100 years) and younger individuals, with the highest absolute risk in this older age group.
Study context
- Population
- Adults aged 20 to 100 years from the Copenhagen General Population Study (primary prevention cohort)18,322 (18%) aged 70 to 100 years
- Exposure
- Higher vs lower lipoprotein, by age group
- Outcome
- ASCVD incidence and HR associated with higher lipoprotein(a), by age
- Follow-up
- Median 12.5 years
Main finding
As reported in the abstract
ASCVD incidence increase per 50 mg/dL (105 nmol/L) higher lipoprotein(a)
| Group | Value | Increase at lipoprotein(a) 70 to 89 mg/dL | Increase at lipoprotein(a) 90 to 426 mg/dL |
|---|---|---|---|
| 20 to 49 years | 0.3 (95% CI 0.2–0.4) per 1000 person-years | 2.7 | 3.2 |
| 50 to 59 years | 0.8 (95% CI 0.6–0.9) per 1000 person-years | 7.1 | 8.3 |
| 60 to 69 years | 1.5 (95% CI 1.2–1.7) per 1000 person-years | 13.3 | 15.6 |
| 70 to 79 years | 2.7 (95% CI 2.2–3.2) per 1000 person-years | 24.4 | 28.7 |
| 80 to 100 years | 4.5 (95% CI 3.7–5.4) per 1000 person-years | 40.9 | 48 |
Observational data: associations, not effects.
Further findings
Atherosclerotic cardiovascular diseases (ASCVD) incidence increase, by sex
- Results similar in women and men, with the highest incidence increases in men
Original publication
Lipoprotein(a) and Atherosclerotic Cardiovascular Disease Among Adults Aged 20 to 100 Years. Circulation. Published 30 August 2026. doi:10.1161/circulationaha.126.079412
Summarised from the published abstract; every number is checked against it