Lipoprotein(a) and Long-Term Plaque Progression, Low-Density Plaque, and Pericoronary Inflammation
An erratum to this article was published (JAMA Cardiol, 1 Sep 2024 ↗)
Authors' conclusion
In this long-term prospective serial CCTA imaging study, higher Lp(a) levels were associated with increased progression of coronary plaque burden and increased presence of low-density noncalcified plaque and pericoronary adipose tissue inflammation.
Study context
- Population
- Patients with suspected coronary artery disease (CAD) undergoing repeated coronary computed tomography angiography (CCTA) 10 years apart (excluding CABG)299 enrolled
- Participants
- 267 patients
- Exposure
- Lp ≥125 nmol/L vs <125 nmol/L
- Outcome
- Change in percent plaque volumes (linear mixed-effects models adjusted for clinical risk factors)
- Follow-up
- Median scan interval 10.2 years
Methodological detailssingle-centre, serial CCTA, interscan interval 10 years
- Single-centre
- Serial CCTA, interscan interval 10 years
Main finding
As reported in the abstract
Percent atheroma volume
P = 0.01
- Per doubling of Lp(a), additional increment in percent atheroma volume over 10 years (adjusted)
- 0.32% (95% CI, 0.04-0.60)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (95% CI) | |
|---|---|---|
| Presence of low-density plaque, per doubling of Lp(a) · baseline and follow-upLp(a) per doubling · baseline | 1.23 (1.00–1.51) | |
| Presence of low-density plaque, per doubling of Lp(a) · baseline and follow-upLp(a) per doubling · follow-up | 1.21 (1.01–1.45) | |
| 0.512Odds ratio (log scale) |
Pericoronary adipose tissue attenuation (RCA and LAD) · baseline and follow-up
- Increased with higher Lp(a) levels around both RCA and LAD
Original publication
Lipoprotein(a) and Long-Term Plaque Progression, Low-Density Plaque, and Pericoronary Inflammation. JAMA Cardiol. Published 1 September 2024. doi:10.
Summarised from the published abstract; every number is checked against it