Lipoprotein(a) and long-term revascularization burden: a recurrent-event analysis of the UK Biobank
Authors' conclusion
In this large primary prevention cohort, elevated Lp(a) was independently associated with a higher long-term revascularization burden across multiple vascular territories. The association was robust for coronary, supportive for peripheral, and inconclusive for carotid revascularization owing to limited statistical power. These findings, derived from recurrent-event methodology, provide a more complete quantification of Lp(a)-associated cardiovascular procedural risk than time-to-first-event analyses alone.
Study context
- Population
- UK Biobank participants of European ancestry free of ASCVD at baselinemedian follow-up 14.1 years
- Participants
- 237,729 participants
- Exposure
- Lp ≥ 105 vs. <105 nmol/L
- Outcome
- total number of coronary, peripheral, and carotid revascularization procedures per person
- Follow-up
- Median of 14.1 years
Methodological detailsprimary prevention cohort
- Primary prevention cohort
Main finding
As reported in the abstract
Lp(a) ≥ 105 nmol/LEstimate (CI)
Andersen-Gill analysis; higher revascularization rate
HR 1.50(1.42–1.60)
Negative binomial regression; 55% higher rate
IRR 1.55(1.45–1.65)
Per person, as printed
- Revascularization procedures occurred
- 10 731
Observational data: associations, not effects.
Further findings
Revascularization by procedure order
| Comparison | HR (CI) | |
|---|---|---|
| Lp(a) ≥ 105 nmol/LFirst procedure | 1.48 (1.40–1.56) | |
| Lp(a) ≥ 105 nmol/LSecond procedure | 1.28 (1.09–1.50) | |
| Lp(a) ≥ 105 nmol/LThird procedure; non-significant | 1.23 (0.94–1.62) | |
| 0.512Hazard ratio (log scale) |
- Findings were consistent across coronary and peripheral territories
Original publication
Lipoprotein(a) and long-term revascularization burden: a recurrent-event analysis of the UK Biobank. Eur J Prev Cardiol. Published 14 October 2026. doi:10.
Summarised from the published abstract; every number is checked against it